Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota

Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota

Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow and gut microbiota. Here, the authors show that chronic hypoxia predisposes bone marrow stem cells to premature senescence, which may be due to gut dysbiosis and gut microbiota-derived d-ga...

Full description

Saved in:
Bibliographic Details
Main Authors: Junyue Xing, Yongquan Ying, Chenxi Mao, Yiwei Liu, Tingting Wang, Qian Zhao, Xiaoling Zhang, Fuxia Yan, Hao Zhang
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/c8fff85f72c84720a26d9d33ef0b27dd
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:doaj.org-article:c8fff85f72c84720a26d9d33ef0b27dd
record_format dspace
spelling oai:doaj.org-article:c8fff85f72c84720a26d9d33ef0b27dd2021-12-02T16:49:18ZHypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota10.1038/s41467-018-04453-92041-1723https://doaj.org/article/c8fff85f72c84720a26d9d33ef0b27dd2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04453-9https://doaj.org/toc/2041-1723Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow and gut microbiota. Here, the authors show that chronic hypoxia predisposes bone marrow stem cells to premature senescence, which may be due to gut dysbiosis and gut microbiota-derived d-galactose accumulation.Junyue XingYongquan YingChenxi MaoYiwei LiuTingting WangQian ZhaoXiaoling ZhangFuxia YanHao ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Junyue Xing
Yongquan Ying
Chenxi Mao
Yiwei Liu
Tingting Wang
Qian Zhao
Xiaoling Zhang
Fuxia Yan
Hao Zhang
Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
description Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow and gut microbiota. Here, the authors show that chronic hypoxia predisposes bone marrow stem cells to premature senescence, which may be due to gut dysbiosis and gut microbiota-derived d-galactose accumulation.
format article
author Junyue Xing
Yongquan Ying
Chenxi Mao
Yiwei Liu
Tingting Wang
Qian Zhao
Xiaoling Zhang
Fuxia Yan
Hao Zhang
author_facet Junyue Xing
Yongquan Ying
Chenxi Mao
Yiwei Liu
Tingting Wang
Qian Zhao
Xiaoling Zhang
Fuxia Yan
Hao Zhang
author_sort Junyue Xing
title Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_short Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_full Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_fullStr Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_full_unstemmed Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
title_sort hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c8fff85f72c84720a26d9d33ef0b27dd
work_keys_str_mv AT junyuexing hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT yongquanying hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT chenximao hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT yiweiliu hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT tingtingwang hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT qianzhao hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT xiaolingzhang hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT fuxiayan hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
AT haozhang hypoxiainducessenescenceofbonemarrowmesenchymalstemcellsviaalteredgutmicrobiota
_version_ 1718383361762787328

Similar Items