Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.

Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant appears to cause more severe illness nor increased risk of death, the faster spread of the virus is a major threat. Using computational tools, we...

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Autores principales:	Suman Pokhrel, Benjamin R Kraemer, Lucia Lee, Kate Samardzic, Daria Mochly-Rosen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9044de64c9c4b3d92b56c6ee24c1299
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spelling	oai:doaj.org-article:c9044de64c9c4b3d92b56c6ee24c12992021-12-02T20:18:55ZIncreased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.1932-620310.1371/journal.pone.0251426https://doaj.org/article/c9044de64c9c4b3d92b56c6ee24c12992021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251426https://doaj.org/toc/1932-6203Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant appears to cause more severe illness nor increased risk of death, the faster spread of the virus is a major threat. Using computational tools, we found that the new SARS-CoV-2 variants may acquire an increased transmissibility by increasing the propensity of its spike protein to expose the receptor binding domain via proteolysis, perhaps by neutrophil elastase and/or via reduced intramolecular interactions that contribute to the stability of the closed conformation of spike protein. This information leads to the identification of potential treatments to avert the imminent threat of these more transmittable SARS-CoV-2 variants.Suman PokhrelBenjamin R KraemerLucia LeeKate SamardzicDaria Mochly-RosenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251426 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suman Pokhrel Benjamin R Kraemer Lucia Lee Kate Samardzic Daria Mochly-Rosen Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.
description	Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant appears to cause more severe illness nor increased risk of death, the faster spread of the virus is a major threat. Using computational tools, we found that the new SARS-CoV-2 variants may acquire an increased transmissibility by increasing the propensity of its spike protein to expose the receptor binding domain via proteolysis, perhaps by neutrophil elastase and/or via reduced intramolecular interactions that contribute to the stability of the closed conformation of spike protein. This information leads to the identification of potential treatments to avert the imminent threat of these more transmittable SARS-CoV-2 variants.
format	article
author	Suman Pokhrel Benjamin R Kraemer Lucia Lee Kate Samardzic Daria Mochly-Rosen
author_facet	Suman Pokhrel Benjamin R Kraemer Lucia Lee Kate Samardzic Daria Mochly-Rosen
author_sort	Suman Pokhrel
title	Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.
title_short	Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.
title_full	Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.
title_fullStr	Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.
title_full_unstemmed	Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.
title_sort	increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501y.v1 and 501y.v2 sars-cov-2 variants' spike protein-an in silico analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c9044de64c9c4b3d92b56c6ee24c1299
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Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.

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