Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet. Here, the authors present the crystal structures of the human RIPK3:MLKL complex and human RIPK3 kinase alone, which reveal structural di...

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Autores principales:	Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c906a3851c864c11bf414f6e8e863c7b
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spelling	oai:doaj.org-article:c906a3851c864c11bf414f6e8e863c7b2021-11-28T12:31:26ZHuman RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis10.1038/s41467-021-27032-x2041-1723https://doaj.org/article/c906a3851c864c11bf414f6e8e863c7b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27032-xhttps://doaj.org/toc/2041-1723The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet. Here, the authors present the crystal structures of the human RIPK3:MLKL complex and human RIPK3 kinase alone, which reveal structural differences between human and murine RIPK3 and they discuss mechanistic implications.Yanxiang MengKatherine A. DaviesCheree FitzgibbonSamuel N. YoungSarah E. GarnishChristopher R. HorneCindy LuoJean-Marc GarnierLung-Yu LiangAngus D. CowanAndre L. SamsonGuillaume LesseneJarrod J. SandowPeter E. CzabotarJames M. MurphyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanxiang Meng Katherine A. Davies Cheree Fitzgibbon Samuel N. Young Sarah E. Garnish Christopher R. Horne Cindy Luo Jean-Marc Garnier Lung-Yu Liang Angus D. Cowan Andre L. Samson Guillaume Lessene Jarrod J. Sandow Peter E. Czabotar James M. Murphy Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
description	The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet. Here, the authors present the crystal structures of the human RIPK3:MLKL complex and human RIPK3 kinase alone, which reveal structural differences between human and murine RIPK3 and they discuss mechanistic implications.
format	article
author	Yanxiang Meng Katherine A. Davies Cheree Fitzgibbon Samuel N. Young Sarah E. Garnish Christopher R. Horne Cindy Luo Jean-Marc Garnier Lung-Yu Liang Angus D. Cowan Andre L. Samson Guillaume Lessene Jarrod J. Sandow Peter E. Czabotar James M. Murphy
author_facet	Yanxiang Meng Katherine A. Davies Cheree Fitzgibbon Samuel N. Young Sarah E. Garnish Christopher R. Horne Cindy Luo Jean-Marc Garnier Lung-Yu Liang Angus D. Cowan Andre L. Samson Guillaume Lessene Jarrod J. Sandow Peter E. Czabotar James M. Murphy
author_sort	Yanxiang Meng
title	Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
title_short	Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
title_full	Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
title_fullStr	Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
title_full_unstemmed	Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
title_sort	human ripk3 maintains mlkl in an inactive conformation prior to cell death by necroptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c906a3851c864c11bf414f6e8e863c7b
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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

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