Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet. Here, the authors present the crystal structures of the human RIPK3:MLKL complex and human RIPK3 kinase alone, which reveal structural di...

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Main Authors: Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/c906a3851c864c11bf414f6e8e863c7b
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https://doaj.org/article/c906a3851c864c11bf414f6e8e863c7b

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