Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and...

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Main Authors:	Xavier Brenachot, Giorgio Ramadori, Rafael M. Ioris, Christelle Veyrat-Durebex, Jordi Altirriba, Ebru Aras, Sanda Ljubicic, Daisuke Kohno, Salvatore Fabbiano, Sophie Clement, Nicolas Goossens, Mirko Trajkovski, Sheila Harroch, Francesco Negro, Roberto Coppari
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/c9087c97e4584399b00b49105c3d6c1d
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spelling	oai:doaj.org-article:c9087c97e4584399b00b49105c3d6c1d2021-12-02T17:06:06ZHepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance10.1038/s41467-017-02074-22041-1723https://doaj.org/article/c9087c97e4584399b00b49105c3d6c1d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02074-2https://doaj.org/toc/2041-1723During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production.Xavier BrenachotGiorgio RamadoriRafael M. IorisChristelle Veyrat-DurebexJordi AltirribaEbru ArasSanda LjubicicDaisuke KohnoSalvatore FabbianoSophie ClementNicolas GoossensMirko TrajkovskiSheila HarrochFrancesco NegroRoberto CoppariNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xavier Brenachot Giorgio Ramadori Rafael M. Ioris Christelle Veyrat-Durebex Jordi Altirriba Ebru Aras Sanda Ljubicic Daisuke Kohno Salvatore Fabbiano Sophie Clement Nicolas Goossens Mirko Trajkovski Sheila Harroch Francesco Negro Roberto Coppari Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
description	During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production.
format	article
author	Xavier Brenachot Giorgio Ramadori Rafael M. Ioris Christelle Veyrat-Durebex Jordi Altirriba Ebru Aras Sanda Ljubicic Daisuke Kohno Salvatore Fabbiano Sophie Clement Nicolas Goossens Mirko Trajkovski Sheila Harroch Francesco Negro Roberto Coppari
author_facet	Xavier Brenachot Giorgio Ramadori Rafael M. Ioris Christelle Veyrat-Durebex Jordi Altirriba Ebru Aras Sanda Ljubicic Daisuke Kohno Salvatore Fabbiano Sophie Clement Nicolas Goossens Mirko Trajkovski Sheila Harroch Francesco Negro Roberto Coppari
author_sort	Xavier Brenachot
title	Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
title_short	Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
title_full	Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
title_fullStr	Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
title_full_unstemmed	Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
title_sort	hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c9087c97e4584399b00b49105c3d6c1d
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Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

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