The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.

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Bibliographic Details
Main Authors: Chih-Chao Liang, Zhuolun Li, David Lopez-Martinez, William V. Nicholson, Catherine Vénien-Bryan, Martin A. Cohn
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/c919cf65091d44ba84e82fd2b5331de6
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