The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.

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Autores principales: Chih-Chao Liang, Zhuolun Li, David Lopez-Martinez, William V. Nicholson, Catherine Vénien-Bryan, Martin A. Cohn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c919cf65091d44ba84e82fd2b5331de6
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spelling oai:doaj.org-article:c919cf65091d44ba84e82fd2b5331de62021-12-02T16:56:48ZThe FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD210.1038/ncomms121242041-1723https://doaj.org/article/c919cf65091d44ba84e82fd2b5331de62016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12124https://doaj.org/toc/2041-1723FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.Chih-Chao LiangZhuolun LiDavid Lopez-MartinezWilliam V. NicholsonCatherine Vénien-BryanMartin A. CohnNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chih-Chao Liang
Zhuolun Li
David Lopez-Martinez
William V. Nicholson
Catherine Vénien-Bryan
Martin A. Cohn
The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
description FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.
format article
author Chih-Chao Liang
Zhuolun Li
David Lopez-Martinez
William V. Nicholson
Catherine Vénien-Bryan
Martin A. Cohn
author_facet Chih-Chao Liang
Zhuolun Li
David Lopez-Martinez
William V. Nicholson
Catherine Vénien-Bryan
Martin A. Cohn
author_sort Chih-Chao Liang
title The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_short The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_full The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_fullStr The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_full_unstemmed The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
title_sort fancd2–fanci complex is recruited to dna interstrand crosslinks before monoubiquitination of fancd2
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/c919cf65091d44ba84e82fd2b5331de6
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