Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Abstract Screening of a carefully selected library of 5,195 small molecules identified 34 hit compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP sensor, EPAC1. Two of these hits (I942 and I178) were selected for their robust and reproducible inhibitory eff...

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Autores principales: Euan Parnell, Stuart P. McElroy, Jolanta Wiejak, Gemma L. Baillie, Alison Porter, David R. Adams, Holger Rehmann, Brian O. Smith, Stephen J. Yarwood
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/c91ea91952a24175bdc43cc328f5f816
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https://doaj.org/article/c91ea91952a24175bdc43cc328f5f816

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