Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.

Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.

One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B*57 or B*5801...

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Auteurs principaux: Denis R Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M Gray, Carolyn Williamson, CAPRISA 002 Study Team
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2008
Sujets:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/c930c4d75daf4947b374aacfb0fc4d67
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https://doaj.org/article/c930c4d75daf4947b374aacfb0fc4d67

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