Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.

One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B*57 or B*5801...

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Autores principales:	Denis R Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M Gray, Carolyn Williamson, CAPRISA 002 Study Team
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c930c4d75daf4947b374aacfb0fc4d67
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spelling	oai:doaj.org-article:c930c4d75daf4947b374aacfb0fc4d672021-11-25T05:46:39ZTransmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.1553-73661553-737410.1371/journal.ppat.1000033https://doaj.org/article/c930c4d75daf4947b374aacfb0fc4d672008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18369479/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B57 or B5801 alleles, for example, target functionally important parts of the Gag protein. Mutants that escape these CTL responses may have lower fitness than the wild-type and can be associated with slower disease progression. Transmission of the escape variant to individuals without these HLA alleles is associated with rapid reversion to wild-type. However, the question of whether infection with an escape mutant offers an advantage to newly infected hosts has not been addressed. Here we investigate the relationship between the genotypes of transmitted viruses and prognostic markers of disease progression and show that infection with HLA-B57/B5801 escape mutants is associated with lower viral load and higher CD4+ counts.Denis R ChoperaZenda WoodmanKoleka MlisanaMandla MlotshwaDarren P MartinCathal SeoigheFlorette TreurnichtDebra Assis de RosaWinston HideSalim Abdool KarimClive M GrayCarolyn WilliamsonCAPRISA 002 Study TeamPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 3, p e1000033 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Denis R Chopera Zenda Woodman Koleka Mlisana Mandla Mlotshwa Darren P Martin Cathal Seoighe Florette Treurnicht Debra Assis de Rosa Winston Hide Salim Abdool Karim Clive M Gray Carolyn Williamson CAPRISA 002 Study Team Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
description	One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B57 or B5801 alleles, for example, target functionally important parts of the Gag protein. Mutants that escape these CTL responses may have lower fitness than the wild-type and can be associated with slower disease progression. Transmission of the escape variant to individuals without these HLA alleles is associated with rapid reversion to wild-type. However, the question of whether infection with an escape mutant offers an advantage to newly infected hosts has not been addressed. Here we investigate the relationship between the genotypes of transmitted viruses and prognostic markers of disease progression and show that infection with HLA-B57/B5801 escape mutants is associated with lower viral load and higher CD4+ counts.
format	article
author	Denis R Chopera Zenda Woodman Koleka Mlisana Mandla Mlotshwa Darren P Martin Cathal Seoighe Florette Treurnicht Debra Assis de Rosa Winston Hide Salim Abdool Karim Clive M Gray Carolyn Williamson CAPRISA 002 Study Team
author_facet	Denis R Chopera Zenda Woodman Koleka Mlisana Mandla Mlotshwa Darren P Martin Cathal Seoighe Florette Treurnicht Debra Assis de Rosa Winston Hide Salim Abdool Karim Clive M Gray Carolyn Williamson CAPRISA 002 Study Team
author_sort	Denis R Chopera
title	Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
title_short	Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
title_full	Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
title_fullStr	Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
title_full_unstemmed	Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
title_sort	transmission of hiv-1 ctl escape variants provides hla-mismatched recipients with a survival advantage.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/c930c4d75daf4947b374aacfb0fc4d67
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Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.

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