Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

Failure of the ependymal cell layer that lines the ventricular surfaces of the brain can result in fetal hydrocephalus. Park et al. reveal a role for the Hippo pathway gene Yap in the generation of ependymal cells, and show that suppression of Yap is observed in a model of hydrocephalus.

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Autores principales:	Raehee Park, Uk Yeol Moon, Jun Young Park, Lucinda J. Hughes, Randy L. Johnson, Seo-Hee Cho, Seonhee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c946f2033a91434ead953a458b67b434
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spelling	oai:doaj.org-article:c946f2033a91434ead953a458b67b4342021-12-02T16:57:18ZYap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus10.1038/ncomms103292041-1723https://doaj.org/article/c946f2033a91434ead953a458b67b4342016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10329https://doaj.org/toc/2041-1723Failure of the ependymal cell layer that lines the ventricular surfaces of the brain can result in fetal hydrocephalus. Park et al. reveal a role for the Hippo pathway gene Yap in the generation of ependymal cells, and show that suppression of Yap is observed in a model of hydrocephalus.Raehee ParkUk Yeol MoonJun Young ParkLucinda J. HughesRandy L. JohnsonSeo-Hee ChoSeonhee KimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raehee Park Uk Yeol Moon Jun Young Park Lucinda J. Hughes Randy L. Johnson Seo-Hee Cho Seonhee Kim Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
description	Failure of the ependymal cell layer that lines the ventricular surfaces of the brain can result in fetal hydrocephalus. Park et al. reveal a role for the Hippo pathway gene Yap in the generation of ependymal cells, and show that suppression of Yap is observed in a model of hydrocephalus.
format	article
author	Raehee Park Uk Yeol Moon Jun Young Park Lucinda J. Hughes Randy L. Johnson Seo-Hee Cho Seonhee Kim
author_facet	Raehee Park Uk Yeol Moon Jun Young Park Lucinda J. Hughes Randy L. Johnson Seo-Hee Cho Seonhee Kim
author_sort	Raehee Park
title	Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
title_short	Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
title_full	Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
title_fullStr	Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
title_full_unstemmed	Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
title_sort	yap is required for ependymal integrity and is suppressed in lpa-induced hydrocephalus
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c946f2033a91434ead953a458b67b434
work_keys_str_mv	AT raeheepark yapisrequiredforependymalintegrityandissuppressedinlpainducedhydrocephalus AT ukyeolmoon yapisrequiredforependymalintegrityandissuppressedinlpainducedhydrocephalus AT junyoungpark yapisrequiredforependymalintegrityandissuppressedinlpainducedhydrocephalus AT lucindajhughes yapisrequiredforependymalintegrityandissuppressedinlpainducedhydrocephalus AT randyljohnson yapisrequiredforependymalintegrityandissuppressedinlpainducedhydrocephalus AT seoheecho yapisrequiredforependymalintegrityandissuppressedinlpainducedhydrocephalus AT seonheekim yapisrequiredforependymalintegrityandissuppressedinlpainducedhydrocephalus
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Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

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