A naturally protective epitope of limited variability as an influenza vaccine target

Current influenza vaccine approaches largely focus on highly variable epitopes with high immunogenicity or epitopes of low variability that often have low immunogenicity. Here, Thompson et al. identify a highly immunogenic epitope of limited variability in the head domain of the H1 haemagglutinin an...

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Autores principales:	Craig P. Thompson, José Lourenço, Adam A. Walters, Uri Obolski, Matthew Edmans, Duncan S. Palmer, Kreepa Kooblall, George W. Carnell, Daniel O’Connor, Thomas A. Bowden, Oliver G. Pybus, Andrew J. Pollard, Nigel J. Temperton, Teresa Lambe, Sarah C. Gilbert, Sunetra Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c958d9080c9c42db8c6590f1627c062e
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spelling	oai:doaj.org-article:c958d9080c9c42db8c6590f1627c062e2021-12-02T17:31:27ZA naturally protective epitope of limited variability as an influenza vaccine target10.1038/s41467-018-06228-82041-1723https://doaj.org/article/c958d9080c9c42db8c6590f1627c062e2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06228-8https://doaj.org/toc/2041-1723Current influenza vaccine approaches largely focus on highly variable epitopes with high immunogenicity or epitopes of low variability that often have low immunogenicity. Here, Thompson et al. identify a highly immunogenic epitope of limited variability in the head domain of the H1 haemagglutinin and show protection from diverse H1N1 strains in mice.Craig P. ThompsonJosé LourençoAdam A. WaltersUri ObolskiMatthew EdmansDuncan S. PalmerKreepa KooblallGeorge W. CarnellDaniel O’ConnorThomas A. BowdenOliver G. PybusAndrew J. PollardNigel J. TempertonTeresa LambeSarah C. GilbertSunetra GuptaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Craig P. Thompson José Lourenço Adam A. Walters Uri Obolski Matthew Edmans Duncan S. Palmer Kreepa Kooblall George W. Carnell Daniel O’Connor Thomas A. Bowden Oliver G. Pybus Andrew J. Pollard Nigel J. Temperton Teresa Lambe Sarah C. Gilbert Sunetra Gupta A naturally protective epitope of limited variability as an influenza vaccine target
description	Current influenza vaccine approaches largely focus on highly variable epitopes with high immunogenicity or epitopes of low variability that often have low immunogenicity. Here, Thompson et al. identify a highly immunogenic epitope of limited variability in the head domain of the H1 haemagglutinin and show protection from diverse H1N1 strains in mice.
format	article
author	Craig P. Thompson José Lourenço Adam A. Walters Uri Obolski Matthew Edmans Duncan S. Palmer Kreepa Kooblall George W. Carnell Daniel O’Connor Thomas A. Bowden Oliver G. Pybus Andrew J. Pollard Nigel J. Temperton Teresa Lambe Sarah C. Gilbert Sunetra Gupta
author_facet	Craig P. Thompson José Lourenço Adam A. Walters Uri Obolski Matthew Edmans Duncan S. Palmer Kreepa Kooblall George W. Carnell Daniel O’Connor Thomas A. Bowden Oliver G. Pybus Andrew J. Pollard Nigel J. Temperton Teresa Lambe Sarah C. Gilbert Sunetra Gupta
author_sort	Craig P. Thompson
title	A naturally protective epitope of limited variability as an influenza vaccine target
title_short	A naturally protective epitope of limited variability as an influenza vaccine target
title_full	A naturally protective epitope of limited variability as an influenza vaccine target
title_fullStr	A naturally protective epitope of limited variability as an influenza vaccine target
title_full_unstemmed	A naturally protective epitope of limited variability as an influenza vaccine target
title_sort	naturally protective epitope of limited variability as an influenza vaccine target
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c958d9080c9c42db8c6590f1627c062e
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A naturally protective epitope of limited variability as an influenza vaccine target

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