Is the Oral Microbiome Important in HIV-Associated Inflammation?

ABSTRACT Alterations in the gut microbiome during HIV infection have been implicated in chronic inflammation, but the role of the oral microbiome in this process is less clear. The article by M. K. Annavajhala, S. D. Khan, S. B. Sullivan, J. Shah, et al. (mSphere 5:e00798-19, 2020, https://doi.org/1...

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Main Author:	Jennifer A. Fulcher
Format:	article
Language:	EN
Published:	American Society for Microbiology 2020
Subjects:	human immunodeficiency virus inflammation oral microbiology Microbiology QR1-502
Online Access:	https://doaj.org/article/c95949f0760a410faa84aa274461dba1
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spelling	oai:doaj.org-article:c95949f0760a410faa84aa274461dba12021-11-15T15:27:54ZIs the Oral Microbiome Important in HIV-Associated Inflammation?10.1128/mSphere.00034-202379-5042https://doaj.org/article/c95949f0760a410faa84aa274461dba12020-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00034-20https://doaj.org/toc/2379-5042ABSTRACT Alterations in the gut microbiome during HIV infection have been implicated in chronic inflammation, but the role of the oral microbiome in this process is less clear. The article by M. K. Annavajhala, S. D. Khan, S. B. Sullivan, J. Shah, et al. (mSphere 5:e00798-19, 2020, https://doi.org/10.1128/mSphere.00798-19) investigated the relationship between oral and gut microbiome diversity and immune activation in patients with HIV on antiretroviral therapy. In this study, oral microbiome diversity was inversely associated with inflammatory markers such as soluble CD14 (sCD14), but surprisingly similar associations were not seen with gut microbiome diversity. Oral microbiome diversity was also associated with periodontitis in these patients. This study highlights the importance of continuing multisite examinations in studying the gastrointestinal tract microbiome and also stimulates important directions for future research defining the role of the oral-gut axis in HIV-associated inflammation.Jennifer A. FulcherAmerican Society for Microbiologyarticlehuman immunodeficiency virusinflammationoral microbiologyMicrobiologyQR1-502ENmSphere, Vol 5, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	human immunodeficiency virus inflammation oral microbiology Microbiology QR1-502
spellingShingle	human immunodeficiency virus inflammation oral microbiology Microbiology QR1-502 Jennifer A. Fulcher Is the Oral Microbiome Important in HIV-Associated Inflammation?
description	ABSTRACT Alterations in the gut microbiome during HIV infection have been implicated in chronic inflammation, but the role of the oral microbiome in this process is less clear. The article by M. K. Annavajhala, S. D. Khan, S. B. Sullivan, J. Shah, et al. (mSphere 5:e00798-19, 2020, https://doi.org/10.1128/mSphere.00798-19) investigated the relationship between oral and gut microbiome diversity and immune activation in patients with HIV on antiretroviral therapy. In this study, oral microbiome diversity was inversely associated with inflammatory markers such as soluble CD14 (sCD14), but surprisingly similar associations were not seen with gut microbiome diversity. Oral microbiome diversity was also associated with periodontitis in these patients. This study highlights the importance of continuing multisite examinations in studying the gastrointestinal tract microbiome and also stimulates important directions for future research defining the role of the oral-gut axis in HIV-associated inflammation.
format	article
author	Jennifer A. Fulcher
author_facet	Jennifer A. Fulcher
author_sort	Jennifer A. Fulcher
title	Is the Oral Microbiome Important in HIV-Associated Inflammation?
title_short	Is the Oral Microbiome Important in HIV-Associated Inflammation?
title_full	Is the Oral Microbiome Important in HIV-Associated Inflammation?
title_fullStr	Is the Oral Microbiome Important in HIV-Associated Inflammation?
title_full_unstemmed	Is the Oral Microbiome Important in HIV-Associated Inflammation?
title_sort	is the oral microbiome important in hiv-associated inflammation?
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/c95949f0760a410faa84aa274461dba1
work_keys_str_mv	AT jenniferafulcher istheoralmicrobiomeimportantinhivassociatedinflammation
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Is the Oral Microbiome Important in HIV-Associated Inflammation?

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