The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway

The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway

The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites.

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Auteurs principaux: Joel C. Rosenbaum, Braulio Bonilla, Sarah R. Hengel, Tony M. Mertz, Benjamin W. Herken, Hinke G. Kazemier, Catherine A. Pressimone, Timothy C. Ratterman, Ellen MacNary, Alessio De Magis, Youngho Kwon, Stephen K. Godin, Bennett Van Houten, Daniel P. Normolle, Patrick Sung, Subha R. Das, Katrin Paeschke, Steven A. Roberts, Andrew P. VanDemark, Kara A. Bernstein
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/c959b07076c14325a2928af04c0eea82
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Internet

https://doaj.org/article/c959b07076c14325a2928af04c0eea82

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