The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway
The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites.
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Nature Portfolio
2019
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oai:doaj.org-article:c959b07076c14325a2928af04c0eea822021-12-02T16:57:53ZThe Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway10.1038/s41467-019-11374-82041-1723https://doaj.org/article/c959b07076c14325a2928af04c0eea822019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11374-8https://doaj.org/toc/2041-1723The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites.Joel C. RosenbaumBraulio BonillaSarah R. HengelTony M. MertzBenjamin W. HerkenHinke G. KazemierCatherine A. PressimoneTimothy C. RattermanEllen MacNaryAlessio De MagisYoungho KwonStephen K. GodinBennett Van HoutenDaniel P. NormollePatrick SungSubha R. DasKatrin PaeschkeSteven A. RobertsAndrew P. VanDemarkKara A. BernsteinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Joel C. Rosenbaum Braulio Bonilla Sarah R. Hengel Tony M. Mertz Benjamin W. Herken Hinke G. Kazemier Catherine A. Pressimone Timothy C. Ratterman Ellen MacNary Alessio De Magis Youngho Kwon Stephen K. Godin Bennett Van Houten Daniel P. Normolle Patrick Sung Subha R. Das Katrin Paeschke Steven A. Roberts Andrew P. VanDemark Kara A. Bernstein The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway |
| description |
The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites. |
| format |
article |
| author |
Joel C. Rosenbaum Braulio Bonilla Sarah R. Hengel Tony M. Mertz Benjamin W. Herken Hinke G. Kazemier Catherine A. Pressimone Timothy C. Ratterman Ellen MacNary Alessio De Magis Youngho Kwon Stephen K. Godin Bennett Van Houten Daniel P. Normolle Patrick Sung Subha R. Das Katrin Paeschke Steven A. Roberts Andrew P. VanDemark Kara A. Bernstein |
| author_facet |
Joel C. Rosenbaum Braulio Bonilla Sarah R. Hengel Tony M. Mertz Benjamin W. Herken Hinke G. Kazemier Catherine A. Pressimone Timothy C. Ratterman Ellen MacNary Alessio De Magis Youngho Kwon Stephen K. Godin Bennett Van Houten Daniel P. Normolle Patrick Sung Subha R. Das Katrin Paeschke Steven A. Roberts Andrew P. VanDemark Kara A. Bernstein |
| author_sort |
Joel C. Rosenbaum |
| title |
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway |
| title_short |
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway |
| title_full |
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway |
| title_fullStr |
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway |
| title_full_unstemmed |
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway |
| title_sort |
rad51 paralogs facilitate a novel dna strand specific damage tolerance pathway |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c959b07076c14325a2928af04c0eea82 |
| work_keys_str_mv |
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