Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration

Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration

Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensive gene flow with limited positive selection sugges...

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Autores principales: Duncan J. Berger, Thomas Crellen, Poppy H. L. Lamberton, Fiona Allan, Alan Tracey, Jennifer D. Noonan, Narcis B. Kabatereine, Edridah M. Tukahebwa, Moses Adriko, Nancy Holroyd, Joanne P. Webster, Matthew Berriman, James A. Cotton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c962db34a2b7473d882bdf56bb9ca5af
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Sumario:Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensive gene flow with limited positive selection suggesting minimal change post MDA.

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