Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration

Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensive gene flow with limited positive selection sugges...

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Autores principales:	Duncan J. Berger, Thomas Crellen, Poppy H. L. Lamberton, Fiona Allan, Alan Tracey, Jennifer D. Noonan, Narcis B. Kabatereine, Edridah M. Tukahebwa, Moses Adriko, Nancy Holroyd, Joanne P. Webster, Matthew Berriman, James A. Cotton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c962db34a2b7473d882bdf56bb9ca5af
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spelling	oai:doaj.org-article:c962db34a2b7473d882bdf56bb9ca5af2021-12-02T14:53:37ZWhole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration10.1038/s41467-021-24958-02041-1723https://doaj.org/article/c962db34a2b7473d882bdf56bb9ca5af2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24958-0https://doaj.org/toc/2041-1723Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensive gene flow with limited positive selection suggesting minimal change post MDA.Duncan J. BergerThomas CrellenPoppy H. L. LambertonFiona AllanAlan TraceyJennifer D. NoonanNarcis B. KabatereineEdridah M. TukahebwaMoses AdrikoNancy HolroydJoanne P. WebsterMatthew BerrimanJames A. CottonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Duncan J. Berger Thomas Crellen Poppy H. L. Lamberton Fiona Allan Alan Tracey Jennifer D. Noonan Narcis B. Kabatereine Edridah M. Tukahebwa Moses Adriko Nancy Holroyd Joanne P. Webster Matthew Berriman James A. Cotton Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
description	Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensive gene flow with limited positive selection suggesting minimal change post MDA.
format	article
author	Duncan J. Berger Thomas Crellen Poppy H. L. Lamberton Fiona Allan Alan Tracey Jennifer D. Noonan Narcis B. Kabatereine Edridah M. Tukahebwa Moses Adriko Nancy Holroyd Joanne P. Webster Matthew Berriman James A. Cotton
author_facet	Duncan J. Berger Thomas Crellen Poppy H. L. Lamberton Fiona Allan Alan Tracey Jennifer D. Noonan Narcis B. Kabatereine Edridah M. Tukahebwa Moses Adriko Nancy Holroyd Joanne P. Webster Matthew Berriman James A. Cotton
author_sort	Duncan J. Berger
title	Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
title_short	Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
title_full	Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
title_fullStr	Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
title_full_unstemmed	Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
title_sort	whole-genome sequencing of schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c962db34a2b7473d882bdf56bb9ca5af
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Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration

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