Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models

Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models

Here, the authors report bi-functional, wide tropic macrocycles that bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion and show efficacy in preventing severe pneumonia at later stages of infection in mouse and non-human primate cyno...

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Autores principales: Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Thi Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c9870560bd824a40938a1a8131ac4429
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spelling oai:doaj.org-article:c9870560bd824a40938a1a8131ac44292021-12-02T15:36:28ZMacrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models10.1038/s41467-021-22964-w2041-1723https://doaj.org/article/c9870560bd824a40938a1a8131ac44292021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22964-whttps://doaj.org/toc/2041-1723Here, the authors report bi-functional, wide tropic macrocycles that bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion and show efficacy in preventing severe pneumonia at later stages of infection in mouse and non-human primate cynomolgus macaque models.Makoto SaitoYasushi ItohFumihiko YasuiTsubasa MunakataDaisuke YamaneMakoto OzawaRisa ItoTakayuki KatohHirohito IshigakiMisako NakayamaShintaro ShichinoheKenzaburo YamajiNaoki YamamotoAi IkejiriTomoko HondaTakahiro SanadaYoshihiro SakodaHiroshi KidaThi Quynh Mai LeYoshihiro KawaokaKazumasa OgasawaraKyoko Tsukiyama-KoharaHiroaki SugaMichinori KoharaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Makoto Saito
Yasushi Itoh
Fumihiko Yasui
Tsubasa Munakata
Daisuke Yamane
Makoto Ozawa
Risa Ito
Takayuki Katoh
Hirohito Ishigaki
Misako Nakayama
Shintaro Shichinohe
Kenzaburo Yamaji
Naoki Yamamoto
Ai Ikejiri
Tomoko Honda
Takahiro Sanada
Yoshihiro Sakoda
Hiroshi Kida
Thi Quynh Mai Le
Yoshihiro Kawaoka
Kazumasa Ogasawara
Kyoko Tsukiyama-Kohara
Hiroaki Suga
Michinori Kohara
Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
description Here, the authors report bi-functional, wide tropic macrocycles that bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion and show efficacy in preventing severe pneumonia at later stages of infection in mouse and non-human primate cynomolgus macaque models.
format article
author Makoto Saito
Yasushi Itoh
Fumihiko Yasui
Tsubasa Munakata
Daisuke Yamane
Makoto Ozawa
Risa Ito
Takayuki Katoh
Hirohito Ishigaki
Misako Nakayama
Shintaro Shichinohe
Kenzaburo Yamaji
Naoki Yamamoto
Ai Ikejiri
Tomoko Honda
Takahiro Sanada
Yoshihiro Sakoda
Hiroshi Kida
Thi Quynh Mai Le
Yoshihiro Kawaoka
Kazumasa Ogasawara
Kyoko Tsukiyama-Kohara
Hiroaki Suga
Michinori Kohara
author_facet Makoto Saito
Yasushi Itoh
Fumihiko Yasui
Tsubasa Munakata
Daisuke Yamane
Makoto Ozawa
Risa Ito
Takayuki Katoh
Hirohito Ishigaki
Misako Nakayama
Shintaro Shichinohe
Kenzaburo Yamaji
Naoki Yamamoto
Ai Ikejiri
Tomoko Honda
Takahiro Sanada
Yoshihiro Sakoda
Hiroshi Kida
Thi Quynh Mai Le
Yoshihiro Kawaoka
Kazumasa Ogasawara
Kyoko Tsukiyama-Kohara
Hiroaki Suga
Michinori Kohara
author_sort Makoto Saito
title Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
title_short Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
title_full Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
title_fullStr Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
title_full_unstemmed Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
title_sort macrocyclic peptides exhibit antiviral effects against influenza virus ha and prevent pneumonia in animal models
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c9870560bd824a40938a1a8131ac4429
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