Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Immune cells produce reactive oxygen species (ROS) to eliminate pathogens, but cell-spontaneous death and ageing may also be induced. Here the authors show that, upon sensing ROS, Mst1/2 kinases modulate the activity of Nrf2 transcription factor and downstream genetic programs to protect mouse macro...

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Autores principales: Ping Wang, Jing Geng, Jiahui Gao, Hao Zhao, Junhong Li, Yiran Shi, Bingying Yang, Chen Xiao, Yueyue Linghu, Xiufeng Sun, Xin Chen, Lixin Hong, Funiu Qin, Xun Li, Jau-Song Yu, Han You, Zengqiang Yuan, Dawang Zhou, Randy L. Johnson, Lanfen Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c991940c4c9e4e0eb76270e8ea3e81c9
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https://doaj.org/article/c991940c4c9e4e0eb76270e8ea3e81c9

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