Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis
Immune cells produce reactive oxygen species (ROS) to eliminate pathogens, but cell-spontaneous death and ageing may also be induced. Here the authors show that, upon sensing ROS, Mst1/2 kinases modulate the activity of Nrf2 transcription factor and downstream genetic programs to protect mouse macro...
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Nature Portfolio
2019
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oai:doaj.org-article:c991940c4c9e4e0eb76270e8ea3e81c92021-12-02T14:38:43ZMacrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis10.1038/s41467-019-08680-62041-1723https://doaj.org/article/c991940c4c9e4e0eb76270e8ea3e81c92019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08680-6https://doaj.org/toc/2041-1723Immune cells produce reactive oxygen species (ROS) to eliminate pathogens, but cell-spontaneous death and ageing may also be induced. Here the authors show that, upon sensing ROS, Mst1/2 kinases modulate the activity of Nrf2 transcription factor and downstream genetic programs to protect mouse macrophages from death and ageing.Ping WangJing GengJiahui GaoHao ZhaoJunhong LiYiran ShiBingying YangChen XiaoYueyue LinghuXiufeng SunXin ChenLixin HongFuniu QinXun LiJau-Song YuHan YouZengqiang YuanDawang ZhouRandy L. JohnsonLanfen ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ping Wang Jing Geng Jiahui Gao Hao Zhao Junhong Li Yiran Shi Bingying Yang Chen Xiao Yueyue Linghu Xiufeng Sun Xin Chen Lixin Hong Funiu Qin Xun Li Jau-Song Yu Han You Zengqiang Yuan Dawang Zhou Randy L. Johnson Lanfen Chen Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis |
| description |
Immune cells produce reactive oxygen species (ROS) to eliminate pathogens, but cell-spontaneous death and ageing may also be induced. Here the authors show that, upon sensing ROS, Mst1/2 kinases modulate the activity of Nrf2 transcription factor and downstream genetic programs to protect mouse macrophages from death and ageing. |
| format |
article |
| author |
Ping Wang Jing Geng Jiahui Gao Hao Zhao Junhong Li Yiran Shi Bingying Yang Chen Xiao Yueyue Linghu Xiufeng Sun Xin Chen Lixin Hong Funiu Qin Xun Li Jau-Song Yu Han You Zengqiang Yuan Dawang Zhou Randy L. Johnson Lanfen Chen |
| author_facet |
Ping Wang Jing Geng Jiahui Gao Hao Zhao Junhong Li Yiran Shi Bingying Yang Chen Xiao Yueyue Linghu Xiufeng Sun Xin Chen Lixin Hong Funiu Qin Xun Li Jau-Song Yu Han You Zengqiang Yuan Dawang Zhou Randy L. Johnson Lanfen Chen |
| author_sort |
Ping Wang |
| title |
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis |
| title_short |
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis |
| title_full |
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis |
| title_fullStr |
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis |
| title_full_unstemmed |
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis |
| title_sort |
macrophage achieves self-protection against oxidative stress-induced ageing through the mst-nrf2 axis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c991940c4c9e4e0eb76270e8ea3e81c9 |
| work_keys_str_mv |
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1718390919061831680 |