Intrinsic limits to gene regulation by global crosstalk

Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.

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Autores principales:	Tamar Friedlander, Roshan Prizak, Călin C. Guet, Nicholas H. Barton, Gašper Tkačik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c992d8eba18c4f6c9db2333ee90aa8f3
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spelling	oai:doaj.org-article:c992d8eba18c4f6c9db2333ee90aa8f32021-12-02T17:32:39ZIntrinsic limits to gene regulation by global crosstalk10.1038/ncomms123072041-1723https://doaj.org/article/c992d8eba18c4f6c9db2333ee90aa8f32016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12307https://doaj.org/toc/2041-1723Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.Tamar FriedlanderRoshan PrizakCălin C. GuetNicholas H. BartonGašper TkačikNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik Intrinsic limits to gene regulation by global crosstalk
description	Limited specificity of transcription factor-DNA interactions leads to crosstalk in gene regulation. Here the authors consider global crosstalk in regulatory networks of growing size and complexity, and show that it imposes constraints on gene regulation and on the evolution of regulatory networks.
format	article
author	Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik
author_facet	Tamar Friedlander Roshan Prizak Călin C. Guet Nicholas H. Barton Gašper Tkačik
author_sort	Tamar Friedlander
title	Intrinsic limits to gene regulation by global crosstalk
title_short	Intrinsic limits to gene regulation by global crosstalk
title_full	Intrinsic limits to gene regulation by global crosstalk
title_fullStr	Intrinsic limits to gene regulation by global crosstalk
title_full_unstemmed	Intrinsic limits to gene regulation by global crosstalk
title_sort	intrinsic limits to gene regulation by global crosstalk
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c992d8eba18c4f6c9db2333ee90aa8f3
work_keys_str_mv	AT tamarfriedlander intrinsiclimitstogeneregulationbyglobalcrosstalk AT roshanprizak intrinsiclimitstogeneregulationbyglobalcrosstalk AT calincguet intrinsiclimitstogeneregulationbyglobalcrosstalk AT nicholashbarton intrinsiclimitstogeneregulationbyglobalcrosstalk AT gaspertkacik intrinsiclimitstogeneregulationbyglobalcrosstalk
_version_	1718380276075200512

Intrinsic limits to gene regulation by global crosstalk

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