Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance
Cas13b can be harnessed to target and degrade RNA transcripts inside a cellular environment. Here the authors reprogram Cas13b to target SARSCoV-2 transcripts in infected mammalian cells and reveal its resilience to variants thanks to single mismatch tolerance.
Guardado en:
Autores principales: | Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua M. L. Casan, Amit Kumar, Jori Symons, Jennifer M. Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G. Ekert, Rajeev Rudraraju, Damian F. J. Purcell, Sharon R. Lewin, Joseph A. Trapani |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c9a22d0a72d14aecb6991c4771cee7a6 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Phenotypic mismatches reveal escape from arms-race coevolution.
por: Charles T Hanifin, et al.
Publicado: (2008) -
Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor
por: Dor Russ, et al.
Publicado: (2020) -
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
por: Denis R Chopera, et al.
Publicado: (2008) -
Novel approaches to circumvent the devastating effects of pests on sugarcane
por: Zahida Qamar, et al.
Publicado: (2021) -
From Finding a Niche to Circumventing Institutional Constraints
por: Katy Jordan
Publicado: (2019)