Single molecule high-throughput footprinting of small and large DNA ligands

Mapping the sequence specificity of DNA ligands remains a challenge, particularly for small drugs. Here the authors develop a parallelized single molecule magnetic tweezers approach using engineered DNA hairpins that can detect sequence selectivity, thermodynamics and kinetics of binding for small d...

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Autores principales: Maria Manosas, Joan Camunas-Soler, Vincent Croquette, Felix Ritort
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c9ac960182d347a292e4a7983f566da9
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