Single molecule high-throughput footprinting of small and large DNA ligands

Mapping the sequence specificity of DNA ligands remains a challenge, particularly for small drugs. Here the authors develop a parallelized single molecule magnetic tweezers approach using engineered DNA hairpins that can detect sequence selectivity, thermodynamics and kinetics of binding for small d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria Manosas, Joan Camunas-Soler, Vincent Croquette, Felix Ritort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9ac960182d347a292e4a7983f566da9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c9ac960182d347a292e4a7983f566da9
record_format	dspace
spelling	oai:doaj.org-article:c9ac960182d347a292e4a7983f566da92021-12-02T13:57:54ZSingle molecule high-throughput footprinting of small and large DNA ligands10.1038/s41467-017-00379-w2041-1723https://doaj.org/article/c9ac960182d347a292e4a7983f566da92017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00379-whttps://doaj.org/toc/2041-1723Mapping the sequence specificity of DNA ligands remains a challenge, particularly for small drugs. Here the authors develop a parallelized single molecule magnetic tweezers approach using engineered DNA hairpins that can detect sequence selectivity, thermodynamics and kinetics of binding for small drugs and large proteins.Maria ManosasJoan Camunas-SolerVincent CroquetteFelix RitortNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Manosas Joan Camunas-Soler Vincent Croquette Felix Ritort Single molecule high-throughput footprinting of small and large DNA ligands
description	Mapping the sequence specificity of DNA ligands remains a challenge, particularly for small drugs. Here the authors develop a parallelized single molecule magnetic tweezers approach using engineered DNA hairpins that can detect sequence selectivity, thermodynamics and kinetics of binding for small drugs and large proteins.
format	article
author	Maria Manosas Joan Camunas-Soler Vincent Croquette Felix Ritort
author_facet	Maria Manosas Joan Camunas-Soler Vincent Croquette Felix Ritort
author_sort	Maria Manosas
title	Single molecule high-throughput footprinting of small and large DNA ligands
title_short	Single molecule high-throughput footprinting of small and large DNA ligands
title_full	Single molecule high-throughput footprinting of small and large DNA ligands
title_fullStr	Single molecule high-throughput footprinting of small and large DNA ligands
title_full_unstemmed	Single molecule high-throughput footprinting of small and large DNA ligands
title_sort	single molecule high-throughput footprinting of small and large dna ligands
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c9ac960182d347a292e4a7983f566da9
work_keys_str_mv	AT mariamanosas singlemoleculehighthroughputfootprintingofsmallandlargednaligands AT joancamunassoler singlemoleculehighthroughputfootprintingofsmallandlargednaligands AT vincentcroquette singlemoleculehighthroughputfootprintingofsmallandlargednaligands AT felixritort singlemoleculehighthroughputfootprintingofsmallandlargednaligands
_version_	1718392286226677760

Single molecule high-throughput footprinting of small and large DNA ligands

Ejemplares similares