Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The molecular processes that lead to neuroendocrine prostate cancer after treating prostate adenocarcinoma (PRAD) are not well understood. Here the authors show that regulation by FOXA1 and changes in the epigenomic profile drive the transition from PRAD to a neuroendocrine phenotype.

Guardado en:
Detalles Bibliográficos
Autores principales: Sylvan C. Baca, David Y. Takeda, Ji-Heui Seo, Justin Hwang, Sheng Yu Ku, Rand Arafeh, Taylor Arnoff, Supreet Agarwal, Connor Bell, Edward O’Connor, Xintao Qiu, Sarah Abou Alaiwi, Rosario I. Corona, Marcos A. S. Fonseca, Claudia Giambartolomei, Paloma Cejas, Klothilda Lim, Monica He, Anjali Sheahan, Amin Nassar, Jacob E. Berchuck, Lisha Brown, Holly M. Nguyen, Ilsa M. Coleman, Arja Kaipainen, Navonil De Sarkar, Peter S. Nelson, Colm Morrissey, Keegan Korthauer, Mark M. Pomerantz, Leigh Ellis, Bogdan Pasaniuc, Kate Lawrenson, Kathleen Kelly, Amina Zoubeidi, William C. Hahn, Himisha Beltran, Henry W. Long, Myles Brown, Eva Corey, Matthew L. Freedman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c9b61c7dcf794ef5947cc08ad8806fa3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c9b61c7dcf794ef5947cc08ad8806fa3
record_format dspace
spelling oai:doaj.org-article:c9b61c7dcf794ef5947cc08ad8806fa32021-12-02T18:17:38ZReprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer10.1038/s41467-021-22139-72041-1723https://doaj.org/article/c9b61c7dcf794ef5947cc08ad8806fa32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22139-7https://doaj.org/toc/2041-1723The molecular processes that lead to neuroendocrine prostate cancer after treating prostate adenocarcinoma (PRAD) are not well understood. Here the authors show that regulation by FOXA1 and changes in the epigenomic profile drive the transition from PRAD to a neuroendocrine phenotype.Sylvan C. BacaDavid Y. TakedaJi-Heui SeoJustin HwangSheng Yu KuRand ArafehTaylor ArnoffSupreet AgarwalConnor BellEdward O’ConnorXintao QiuSarah Abou AlaiwiRosario I. CoronaMarcos A. S. FonsecaClaudia GiambartolomeiPaloma CejasKlothilda LimMonica HeAnjali SheahanAmin NassarJacob E. BerchuckLisha BrownHolly M. NguyenIlsa M. ColemanArja KaipainenNavonil De SarkarPeter S. NelsonColm MorrisseyKeegan KorthauerMark M. PomerantzLeigh EllisBogdan PasaniucKate LawrensonKathleen KellyAmina ZoubeidiWilliam C. HahnHimisha BeltranHenry W. LongMyles BrownEva CoreyMatthew L. FreedmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sylvan C. Baca
David Y. Takeda
Ji-Heui Seo
Justin Hwang
Sheng Yu Ku
Rand Arafeh
Taylor Arnoff
Supreet Agarwal
Connor Bell
Edward O’Connor
Xintao Qiu
Sarah Abou Alaiwi
Rosario I. Corona
Marcos A. S. Fonseca
Claudia Giambartolomei
Paloma Cejas
Klothilda Lim
Monica He
Anjali Sheahan
Amin Nassar
Jacob E. Berchuck
Lisha Brown
Holly M. Nguyen
Ilsa M. Coleman
Arja Kaipainen
Navonil De Sarkar
Peter S. Nelson
Colm Morrissey
Keegan Korthauer
Mark M. Pomerantz
Leigh Ellis
Bogdan Pasaniuc
Kate Lawrenson
Kathleen Kelly
Amina Zoubeidi
William C. Hahn
Himisha Beltran
Henry W. Long
Myles Brown
Eva Corey
Matthew L. Freedman
Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
description The molecular processes that lead to neuroendocrine prostate cancer after treating prostate adenocarcinoma (PRAD) are not well understood. Here the authors show that regulation by FOXA1 and changes in the epigenomic profile drive the transition from PRAD to a neuroendocrine phenotype.
format article
author Sylvan C. Baca
David Y. Takeda
Ji-Heui Seo
Justin Hwang
Sheng Yu Ku
Rand Arafeh
Taylor Arnoff
Supreet Agarwal
Connor Bell
Edward O’Connor
Xintao Qiu
Sarah Abou Alaiwi
Rosario I. Corona
Marcos A. S. Fonseca
Claudia Giambartolomei
Paloma Cejas
Klothilda Lim
Monica He
Anjali Sheahan
Amin Nassar
Jacob E. Berchuck
Lisha Brown
Holly M. Nguyen
Ilsa M. Coleman
Arja Kaipainen
Navonil De Sarkar
Peter S. Nelson
Colm Morrissey
Keegan Korthauer
Mark M. Pomerantz
Leigh Ellis
Bogdan Pasaniuc
Kate Lawrenson
Kathleen Kelly
Amina Zoubeidi
William C. Hahn
Himisha Beltran
Henry W. Long
Myles Brown
Eva Corey
Matthew L. Freedman
author_facet Sylvan C. Baca
David Y. Takeda
Ji-Heui Seo
Justin Hwang
Sheng Yu Ku
Rand Arafeh
Taylor Arnoff
Supreet Agarwal
Connor Bell
Edward O’Connor
Xintao Qiu
Sarah Abou Alaiwi
Rosario I. Corona
Marcos A. S. Fonseca
Claudia Giambartolomei
Paloma Cejas
Klothilda Lim
Monica He
Anjali Sheahan
Amin Nassar
Jacob E. Berchuck
Lisha Brown
Holly M. Nguyen
Ilsa M. Coleman
Arja Kaipainen
Navonil De Sarkar
Peter S. Nelson
Colm Morrissey
Keegan Korthauer
Mark M. Pomerantz
Leigh Ellis
Bogdan Pasaniuc
Kate Lawrenson
Kathleen Kelly
Amina Zoubeidi
William C. Hahn
Himisha Beltran
Henry W. Long
Myles Brown
Eva Corey
Matthew L. Freedman
author_sort Sylvan C. Baca
title Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
title_short Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
title_full Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
title_fullStr Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
title_full_unstemmed Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
title_sort reprogramming of the foxa1 cistrome in treatment-emergent neuroendocrine prostate cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c9b61c7dcf794ef5947cc08ad8806fa3
work_keys_str_mv AT sylvancbaca reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT davidytakeda reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT jiheuiseo reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT justinhwang reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT shengyuku reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT randarafeh reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT taylorarnoff reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT supreetagarwal reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT connorbell reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT edwardoconnor reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT xintaoqiu reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT sarahaboualaiwi reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT rosarioicorona reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT marcosasfonseca reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT claudiagiambartolomei reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT palomacejas reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT klothildalim reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT monicahe reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT anjalisheahan reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT aminnassar reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT jacobeberchuck reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT lishabrown reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT hollymnguyen reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT ilsamcoleman reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT arjakaipainen reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT navonildesarkar reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT petersnelson reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT colmmorrissey reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT keegankorthauer reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT markmpomerantz reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT leighellis reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT bogdanpasaniuc reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT katelawrenson reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT kathleenkelly reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT aminazoubeidi reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT williamchahn reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT himishabeltran reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT henrywlong reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT mylesbrown reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT evacorey reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
AT matthewlfreedman reprogrammingofthefoxa1cistromeintreatmentemergentneuroendocrineprostatecancer
_version_ 1718378298792214528

Ejemplares similares