FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xieet al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis.

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Bibliographic Details
Main Authors: Feng Xie, Ke Jin, Li Shao, Yao Fan, Yifei Tu, Yihao Li, Bin Yang, Hans van Dam, Peter ten Dijke, Honglei Weng, Steven Dooley, Shuai Wang, Junling Jia, Jin Jin, Fangfang Zhou, Long Zhang
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/c9d75b7c3d6a4d48b6838665b721268c
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https://doaj.org/article/c9d75b7c3d6a4d48b6838665b721268c

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