FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xieet al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis.

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Autores principales:	Feng Xie, Ke Jin, Li Shao, Yao Fan, Yifei Tu, Yihao Li, Bin Yang, Hans van Dam, Peter ten Dijke, Honglei Weng, Steven Dooley, Shuai Wang, Junling Jia, Jin Jin, Fangfang Zhou, Long Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9d75b7c3d6a4d48b6838665b721268c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c9d75b7c3d6a4d48b6838665b721268c2021-12-02T14:41:09ZFAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis10.1038/ncomms150212041-1723https://doaj.org/article/c9d75b7c3d6a4d48b6838665b721268c2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15021https://doaj.org/toc/2041-1723Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xieet al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis.Feng XieKe JinLi ShaoYao FanYifei TuYihao LiBin YangHans van DamPeter ten DijkeHonglei WengSteven DooleyShuai WangJunling JiaJin JinFangfang ZhouLong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Xie Ke Jin Li Shao Yao Fan Yifei Tu Yihao Li Bin Yang Hans van Dam Peter ten Dijke Honglei Weng Steven Dooley Shuai Wang Junling Jia Jin Jin Fangfang Zhou Long Zhang FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
description	Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xieet al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis.
format	article
author	Feng Xie Ke Jin Li Shao Yao Fan Yifei Tu Yihao Li Bin Yang Hans van Dam Peter ten Dijke Honglei Weng Steven Dooley Shuai Wang Junling Jia Jin Jin Fangfang Zhou Long Zhang
author_facet	Feng Xie Ke Jin Li Shao Yao Fan Yifei Tu Yihao Li Bin Yang Hans van Dam Peter ten Dijke Honglei Weng Steven Dooley Shuai Wang Junling Jia Jin Jin Fangfang Zhou Long Zhang
author_sort	Feng Xie
title	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
title_short	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
title_full	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
title_fullStr	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
title_full_unstemmed	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
title_sort	faf1 phosphorylation by akt accumulates tgf-β type ii receptor and drives breast cancer metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c9d75b7c3d6a4d48b6838665b721268c
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FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

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