Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic

The main factors of botulism transmission are identified as home-canned products (vegetable salads, fruit compotes, seaberry jam), pickled cucumbers and tomatoes. Botulism proceeds clinically as moderate-to-severe disease. High prevalence of type A and untypeable C. botulinum toxins along with type...

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Autores principales:	S. T. Salieva, S. T. Zholdoshev
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	botulism ptosis toxin clinical finding оphthalmoplegic syndrome myoneuroplegia Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ca0297ec29ae4f5d919ab9e1c0dfefb6
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spelling	oai:doaj.org-article:ca0297ec29ae4f5d919ab9e1c0dfefb62021-11-22T07:09:54ZClinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic2220-76192313-739810.15789/2220-7619-CFO-1209https://doaj.org/article/ca0297ec29ae4f5d919ab9e1c0dfefb62020-08-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1209https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The main factors of botulism transmission are identified as home-canned products (vegetable salads, fruit compotes, seaberry jam), pickled cucumbers and tomatoes. Botulism proceeds clinically as moderate-to-severe disease. High prevalence of type A and untypeable C. botulinum toxins along with type B species in the southern region accounts for its severe course. In our study, clinical manifestations of botulism were presented by moderate and severe clinical picture in 72.3% (47 patients) and 27.7% (18 patients) cases. No mild forms of the disease were diagnosed. Length of incubation period in examined patients on average was 13.6 hours. Upon that, a short incubation period was observed after consumption of canned fruit compote and sea buckthorn jam, cucumbers and tomatoes (16 subjects) or canned vegetables (38 subjects) on average ranging from 4 to 8 hours, 8 hours to 1 day, or 15 hours to 1.5 days, respectively. All subjects were featured with acute onset manifested as general intoxication and gastrointestinal syndromes. The former was characterized by headache, dizziness, and severe general weakness. Subfebrile temperature (37.1–37.5°C) was noted in patients with a short incubation period. Such syndrome in case of moderate disease course was also characterized by moderate severity in 70.2±6.7% cases, with acute appearance in 29.8±6.9% cases; in severe course it was featured with extremely severe course (100%), and in one case it resulted in lethal outcome. Intensity and persistence of neurological disorders clearly correlated with the disease severity, which pointed at its progression. Upon admission to the hospital, patients noted moderate and marked dry mouth in 63.1±5.9% and 36.9±5.9% cases, respectively. Ophthalmoplegic syndrome was characterized by: doubling of object contours, diplopia, limited eye movement, mydriasis, lethargy or lack of pupillary reaction to light, anisocoria, and ptosis. Phagonazoglossoneurological syndrome was early manifested by swallowing problem. Next, tongue deviation, amimia, flattened nasolabial fold, and soft palate paresis were added up. Phonolaryngology syndrome was evident depending on disease severity in a form of varying intensity of dysphonia and dysarthria. Syndrome of general myoneuroplegia was characterized by lowered strength in hands and feet.S. T. SalievaS. T. ZholdoshevSankt-Peterburg : NIIÈM imeni Pasteraarticlebotulismptosistoxinclinical findingоphthalmoplegic syndromemyoneuroplegiaInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 3, Pp 581-586 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	botulism ptosis toxin clinical finding оphthalmoplegic syndrome myoneuroplegia Infectious and parasitic diseases RC109-216
spellingShingle	botulism ptosis toxin clinical finding оphthalmoplegic syndrome myoneuroplegia Infectious and parasitic diseases RC109-216 S. T. Salieva S. T. Zholdoshev Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic
description	The main factors of botulism transmission are identified as home-canned products (vegetable salads, fruit compotes, seaberry jam), pickled cucumbers and tomatoes. Botulism proceeds clinically as moderate-to-severe disease. High prevalence of type A and untypeable C. botulinum toxins along with type B species in the southern region accounts for its severe course. In our study, clinical manifestations of botulism were presented by moderate and severe clinical picture in 72.3% (47 patients) and 27.7% (18 patients) cases. No mild forms of the disease were diagnosed. Length of incubation period in examined patients on average was 13.6 hours. Upon that, a short incubation period was observed after consumption of canned fruit compote and sea buckthorn jam, cucumbers and tomatoes (16 subjects) or canned vegetables (38 subjects) on average ranging from 4 to 8 hours, 8 hours to 1 day, or 15 hours to 1.5 days, respectively. All subjects were featured with acute onset manifested as general intoxication and gastrointestinal syndromes. The former was characterized by headache, dizziness, and severe general weakness. Subfebrile temperature (37.1–37.5°C) was noted in patients with a short incubation period. Such syndrome in case of moderate disease course was also characterized by moderate severity in 70.2±6.7% cases, with acute appearance in 29.8±6.9% cases; in severe course it was featured with extremely severe course (100%), and in one case it resulted in lethal outcome. Intensity and persistence of neurological disorders clearly correlated with the disease severity, which pointed at its progression. Upon admission to the hospital, patients noted moderate and marked dry mouth in 63.1±5.9% and 36.9±5.9% cases, respectively. Ophthalmoplegic syndrome was characterized by: doubling of object contours, diplopia, limited eye movement, mydriasis, lethargy or lack of pupillary reaction to light, anisocoria, and ptosis. Phagonazoglossoneurological syndrome was early manifested by swallowing problem. Next, tongue deviation, amimia, flattened nasolabial fold, and soft palate paresis were added up. Phonolaryngology syndrome was evident depending on disease severity in a form of varying intensity of dysphonia and dysarthria. Syndrome of general myoneuroplegia was characterized by lowered strength in hands and feet.
format	article
author	S. T. Salieva S. T. Zholdoshev
author_facet	S. T. Salieva S. T. Zholdoshev
author_sort	S. T. Salieva
title	Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic
title_short	Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic
title_full	Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic
title_fullStr	Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic
title_full_unstemmed	Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic
title_sort	clinical characteristics of foodborne botulism in the southern region of the kyrgyz republic
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/ca0297ec29ae4f5d919ab9e1c0dfefb6
work_keys_str_mv	AT stsalieva clinicalcharacteristicsoffoodbornebotulisminthesouthernregionofthekyrgyzrepublic AT stzholdoshev clinicalcharacteristicsoffoodbornebotulisminthesouthernregionofthekyrgyzrepublic
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Clinical characteristics of foodborne botulism in the southern region of the Kyrgyz Republic

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