A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma

A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma

Uveal melanoma (UM) is a rare subset of melanoma characterized by the presence of early initiating GNAQ/11 mutations, with downstream activation of the PKC, MAPK, and PI3Kα pathways. Activity has been observed with the PKC inhibitors sotrastaurin (AEB071) and darovasertib (IDE196) in patients with U...

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Autores principales: Alexander N. Shoushtari, Shaheer Khan, Kimberly Komatsubara, Lynn Feun, Nicolas Acquavella, Shahnaz Singh-Kandah, Tiffany Negri, Alexandra Nesson, Kelly Abbate, Serge Cremers, Elgilda Musi, Grazia Ambrosini, Shing Lee, Gary K. Schwartz, Richard D. Carvajal
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
uveal melanoma
targeted therapy
sotrastaurin
alpelisib
PKC
PI3K
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/ca14021bac2d473688895d4925fe502f
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https://doaj.org/article/ca14021bac2d473688895d4925fe502f

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