Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment

Features of major depressive disorder including lack of motivation, sleep disruption and cognitive deficit have been modelled in rodents. Here, the authors develop a new method to elicit a depression-like state inDrosophila, and uncover separable roles for different serotonin receptors in depression...

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Autores principales: Ariane-Saskia Ries, Tim Hermanns, Burkhard Poeck, Roland Strauss
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ca4249022afd4ce2abf1cea0c9c7a7d7
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Sumario:Features of major depressive disorder including lack of motivation, sleep disruption and cognitive deficit have been modelled in rodents. Here, the authors develop a new method to elicit a depression-like state inDrosophila, and uncover separable roles for different serotonin receptors in depression-like behaviour.