Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment

Features of major depressive disorder including lack of motivation, sleep disruption and cognitive deficit have been modelled in rodents. Here, the authors develop a new method to elicit a depression-like state inDrosophila, and uncover separable roles for different serotonin receptors in depression...

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Auteurs principaux: Ariane-Saskia Ries, Tim Hermanns, Burkhard Poeck, Roland Strauss
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/ca4249022afd4ce2abf1cea0c9c7a7d7
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Résumé:Features of major depressive disorder including lack of motivation, sleep disruption and cognitive deficit have been modelled in rodents. Here, the authors develop a new method to elicit a depression-like state inDrosophila, and uncover separable roles for different serotonin receptors in depression-like behaviour.