Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity of neural grafts in Parkinsonian rats.

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Autores principales: Isabelle R. de Luzy, Kevin C. L. Law, Niamh Moriarty, Cameron P. J. Hunt, Jennifer C. Durnall, Lachlan H. Thompson, Andras Nagy, Clare L. Parish
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ca572aff55e041bfa62cd27bc82d3238
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