Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity of neural grafts in Parkinsonian rats.
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/ca572aff55e041bfa62cd27bc82d3238 |
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| Sumario: | Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity of neural grafts in Parkinsonian rats. |
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