Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity of neural grafts in Parkinsonian rats.

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Autores principales:	Isabelle R. de Luzy, Kevin C. L. Law, Niamh Moriarty, Cameron P. J. Hunt, Jennifer C. Durnall, Lachlan H. Thompson, Andras Nagy, Clare L. Parish
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca572aff55e041bfa62cd27bc82d3238
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spelling	oai:doaj.org-article:ca572aff55e041bfa62cd27bc82d32382021-12-02T14:49:15ZHuman stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats10.1038/s41467-021-23125-92041-1723https://doaj.org/article/ca572aff55e041bfa62cd27bc82d32382021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23125-9https://doaj.org/toc/2041-1723Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity of neural grafts in Parkinsonian rats.Isabelle R. de LuzyKevin C. L. LawNiamh MoriartyCameron P. J. HuntJennifer C. DurnallLachlan H. ThompsonAndras NagyClare L. ParishNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabelle R. de Luzy Kevin C. L. Law Niamh Moriarty Cameron P. J. Hunt Jennifer C. Durnall Lachlan H. Thompson Andras Nagy Clare L. Parish Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
description	Stem cell grafts present a risk of tissue overgrowth/tumors. Here, the authors utilise a human pluripotent stem cell line carrying a FailSafe suicide gene to not only ablate proliferative cells, but through timely gene activation, improve the purity of neural grafts in Parkinsonian rats.
format	article
author	Isabelle R. de Luzy Kevin C. L. Law Niamh Moriarty Cameron P. J. Hunt Jennifer C. Durnall Lachlan H. Thompson Andras Nagy Clare L. Parish
author_facet	Isabelle R. de Luzy Kevin C. L. Law Niamh Moriarty Cameron P. J. Hunt Jennifer C. Durnall Lachlan H. Thompson Andras Nagy Clare L. Parish
author_sort	Isabelle R. de Luzy
title	Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
title_short	Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
title_full	Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
title_fullStr	Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
title_full_unstemmed	Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
title_sort	human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in parkinsonian rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca572aff55e041bfa62cd27bc82d3238
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Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

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