Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space. Here the authors report a route to 4,5,7,8-substituted antiviral fluorescent quinazolines, to allow cellular uptake visualization without external marker...

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Autores principales:	Felix E. Held, Anton A. Guryev, Tony Fröhlich, Frank Hampel, Axel Kahnt, Corina Hutterer, Mirjam Steingruber, Hanife Bahsi, Clemens von Bojničić-Kninski, Daniela S. Mattes, Tobias C. Foertsch, Alexander Nesterov-Mueller, Manfred Marschall, Svetlana B. Tsogoeva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca6b3826d1e94ad6b59eb0bddea12063
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spelling	oai:doaj.org-article:ca6b3826d1e94ad6b59eb0bddea120632021-12-02T15:38:39ZFacile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions10.1038/ncomms150712041-1723https://doaj.org/article/ca6b3826d1e94ad6b59eb0bddea120632017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15071https://doaj.org/toc/2041-1723Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space. Here the authors report a route to 4,5,7,8-substituted antiviral fluorescent quinazolines, to allow cellular uptake visualization without external marker.Felix E. HeldAnton A. GuryevTony FröhlichFrank HampelAxel KahntCorina HuttererMirjam SteingruberHanife BahsiClemens von Bojničić-KninskiDaniela S. MattesTobias C. FoertschAlexander Nesterov-MuellerManfred MarschallSvetlana B. TsogoevaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Felix E. Held Anton A. Guryev Tony Fröhlich Frank Hampel Axel Kahnt Corina Hutterer Mirjam Steingruber Hanife Bahsi Clemens von Bojničić-Kninski Daniela S. Mattes Tobias C. Foertsch Alexander Nesterov-Mueller Manfred Marschall Svetlana B. Tsogoeva Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
description	Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space. Here the authors report a route to 4,5,7,8-substituted antiviral fluorescent quinazolines, to allow cellular uptake visualization without external marker.
format	article
author	Felix E. Held Anton A. Guryev Tony Fröhlich Frank Hampel Axel Kahnt Corina Hutterer Mirjam Steingruber Hanife Bahsi Clemens von Bojničić-Kninski Daniela S. Mattes Tobias C. Foertsch Alexander Nesterov-Mueller Manfred Marschall Svetlana B. Tsogoeva
author_facet	Felix E. Held Anton A. Guryev Tony Fröhlich Frank Hampel Axel Kahnt Corina Hutterer Mirjam Steingruber Hanife Bahsi Clemens von Bojničić-Kninski Daniela S. Mattes Tobias C. Foertsch Alexander Nesterov-Mueller Manfred Marschall Svetlana B. Tsogoeva
author_sort	Felix E. Held
title	Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
title_short	Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
title_full	Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
title_fullStr	Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
title_full_unstemmed	Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
title_sort	facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ca6b3826d1e94ad6b59eb0bddea12063
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Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

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