Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity

Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed...

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Autores principales:	Dongsheng Li, Min-Hsuan Lin, Daniel J. Rawle, Hongping Jin, Zhonglan Wu, Lu Wang, Mary Lor, Mazhar Hussain, John Aaskov, David Harrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ca6d677537e941f587164eee3d3acebc
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spelling	oai:doaj.org-article:ca6d677537e941f587164eee3d3acebc2021-12-02T17:02:05ZDengue virus-free defective interfering particles have potent and broad anti-dengue virus activity10.1038/s42003-021-02064-72399-3642https://doaj.org/article/ca6d677537e941f587164eee3d3acebc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02064-7https://doaj.org/toc/2399-3642Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed to make antiviral DIPs for other RNA viruses.Dongsheng LiMin-Hsuan LinDaniel J. RawleHongping JinZhonglan WuLu WangMary LorMazhar HussainJohn AaskovDavid HarrichNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Dongsheng Li Min-Hsuan Lin Daniel J. Rawle Hongping Jin Zhonglan Wu Lu Wang Mary Lor Mazhar Hussain John Aaskov David Harrich Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
description	Li et al. produce a dengue virus (DENV)-derived defective interfering particle (DIP) production cell line that can stably produce infectious virusfree DIPs. The DENV DIPs produced from this system can potently inhibit replication of all DENV serotypes in cells and have the potential to be repurposed to make antiviral DIPs for other RNA viruses.
format	article
author	Dongsheng Li Min-Hsuan Lin Daniel J. Rawle Hongping Jin Zhonglan Wu Lu Wang Mary Lor Mazhar Hussain John Aaskov David Harrich
author_facet	Dongsheng Li Min-Hsuan Lin Daniel J. Rawle Hongping Jin Zhonglan Wu Lu Wang Mary Lor Mazhar Hussain John Aaskov David Harrich
author_sort	Dongsheng Li
title	Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_short	Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_full	Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_fullStr	Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_full_unstemmed	Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
title_sort	dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca6d677537e941f587164eee3d3acebc
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Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity

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