Glutamate utilization couples oxidative stress defense and the tricarboxylic acid cycle in Francisella phagosomal escape.

Intracellular bacterial pathogens have developed a variety of strategies to avoid degradation by the host innate immune defense mechanisms triggered upon phagocytocis. Upon infection of mammalian host cells, the intracellular pathogen Francisella replicates exclusively in the cytosolic compartment....

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Auteurs principaux: Elodie Ramond, Gael Gesbert, Mélanie Rigard, Julien Dairou, Marion Dupuis, Iharilalao Dubail, Karin Meibom, Thomas Henry, Monique Barel, Alain Charbit
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
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Accès en ligne:https://doaj.org/article/ca9c6d9a8fcd4e988e24149e35d7aacf
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