Optimizing mitochondrial maintenance in extended neuronal projections.

Neurons rely on localized mitochondria to fulfill spatially heterogeneous metabolic demands. Mitochondrial aging occurs on timescales shorter than the neuronal lifespan, necessitating transport of fresh material from the soma. Maintaining an optimal distribution of healthy mitochondria requires an i...

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Autores principales:	Anamika Agrawal, Elena F Koslover
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/caff8740e8fa484cb5bbe12f3ad495a6
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id	oai:doaj.org-article:caff8740e8fa484cb5bbe12f3ad495a6
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spelling	oai:doaj.org-article:caff8740e8fa484cb5bbe12f3ad495a62021-11-25T05:40:37ZOptimizing mitochondrial maintenance in extended neuronal projections.1553-734X1553-735810.1371/journal.pcbi.1009073https://doaj.org/article/caff8740e8fa484cb5bbe12f3ad495a62021-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009073https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Neurons rely on localized mitochondria to fulfill spatially heterogeneous metabolic demands. Mitochondrial aging occurs on timescales shorter than the neuronal lifespan, necessitating transport of fresh material from the soma. Maintaining an optimal distribution of healthy mitochondria requires an interplay between a stationary pool localized to sites of high metabolic demand and a motile pool capable of delivering new material. Interchange between these pools can occur via transient fusion / fission events or by halting and restarting entire mitochondria. Our quantitative model of neuronal mitostasis identifies key parameters that govern steady-state mitochondrial health at discrete locations. Very infrequent exchange between stationary and motile pools optimizes this system. Exchange via transient fusion allows for robust maintenance, which can be further improved by selective recycling through mitophagy. These results provide a framework for quantifying how perturbations in organelle transport and interactions affect mitochondrial homeostasis in neurons, a key aspect underlying many neurodegenerative disorders.Anamika AgrawalElena F KosloverPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 6, p e1009073 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Anamika Agrawal Elena F Koslover Optimizing mitochondrial maintenance in extended neuronal projections.
description	Neurons rely on localized mitochondria to fulfill spatially heterogeneous metabolic demands. Mitochondrial aging occurs on timescales shorter than the neuronal lifespan, necessitating transport of fresh material from the soma. Maintaining an optimal distribution of healthy mitochondria requires an interplay between a stationary pool localized to sites of high metabolic demand and a motile pool capable of delivering new material. Interchange between these pools can occur via transient fusion / fission events or by halting and restarting entire mitochondria. Our quantitative model of neuronal mitostasis identifies key parameters that govern steady-state mitochondrial health at discrete locations. Very infrequent exchange between stationary and motile pools optimizes this system. Exchange via transient fusion allows for robust maintenance, which can be further improved by selective recycling through mitophagy. These results provide a framework for quantifying how perturbations in organelle transport and interactions affect mitochondrial homeostasis in neurons, a key aspect underlying many neurodegenerative disorders.
format	article
author	Anamika Agrawal Elena F Koslover
author_facet	Anamika Agrawal Elena F Koslover
author_sort	Anamika Agrawal
title	Optimizing mitochondrial maintenance in extended neuronal projections.
title_short	Optimizing mitochondrial maintenance in extended neuronal projections.
title_full	Optimizing mitochondrial maintenance in extended neuronal projections.
title_fullStr	Optimizing mitochondrial maintenance in extended neuronal projections.
title_full_unstemmed	Optimizing mitochondrial maintenance in extended neuronal projections.
title_sort	optimizing mitochondrial maintenance in extended neuronal projections.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/caff8740e8fa484cb5bbe12f3ad495a6
work_keys_str_mv	AT anamikaagrawal optimizingmitochondrialmaintenanceinextendedneuronalprojections AT elenafkoslover optimizingmitochondrialmaintenanceinextendedneuronalprojections
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Optimizing mitochondrial maintenance in extended neuronal projections.

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