Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

P2X receptors are nonselective cation channels that are gated by extracellular ATP. Here the authors present the crystal structure of chicken P2X7 with its bound competitive antagonist TNP-ATP and give mechanistic insights into TNP-ATP dependent inhibition through further computational analysis and...

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Autores principales:	Go Kasuya, Toshiaki Yamaura, Xiao-Bo Ma, Ryoki Nakamura, Mizuki Takemoto, Hiromitsu Nagumo, Eiichi Tanaka, Naoshi Dohmae, Takanori Nakane, Ye Yu, Ryuichiro Ishitani, Osamu Matsuzaki, Motoyuki Hattori, Osamu Nureki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb0f6ce882154f37b17a413f1ef7ef0d
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spelling	oai:doaj.org-article:cb0f6ce882154f37b17a413f1ef7ef0d2021-12-02T17:01:17ZStructural insights into the competitive inhibition of the ATP-gated P2X receptor channel10.1038/s41467-017-00887-92041-1723https://doaj.org/article/cb0f6ce882154f37b17a413f1ef7ef0d2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00887-9https://doaj.org/toc/2041-1723P2X receptors are nonselective cation channels that are gated by extracellular ATP. Here the authors present the crystal structure of chicken P2X7 with its bound competitive antagonist TNP-ATP and give mechanistic insights into TNP-ATP dependent inhibition through further computational analysis and electrophysiology measurements.Go KasuyaToshiaki YamauraXiao-Bo MaRyoki NakamuraMizuki TakemotoHiromitsu NagumoEiichi TanakaNaoshi DohmaeTakanori NakaneYe YuRyuichiro IshitaniOsamu MatsuzakiMotoyuki HattoriOsamu NurekiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Go Kasuya Toshiaki Yamaura Xiao-Bo Ma Ryoki Nakamura Mizuki Takemoto Hiromitsu Nagumo Eiichi Tanaka Naoshi Dohmae Takanori Nakane Ye Yu Ryuichiro Ishitani Osamu Matsuzaki Motoyuki Hattori Osamu Nureki Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
description	P2X receptors are nonselective cation channels that are gated by extracellular ATP. Here the authors present the crystal structure of chicken P2X7 with its bound competitive antagonist TNP-ATP and give mechanistic insights into TNP-ATP dependent inhibition through further computational analysis and electrophysiology measurements.
format	article
author	Go Kasuya Toshiaki Yamaura Xiao-Bo Ma Ryoki Nakamura Mizuki Takemoto Hiromitsu Nagumo Eiichi Tanaka Naoshi Dohmae Takanori Nakane Ye Yu Ryuichiro Ishitani Osamu Matsuzaki Motoyuki Hattori Osamu Nureki
author_facet	Go Kasuya Toshiaki Yamaura Xiao-Bo Ma Ryoki Nakamura Mizuki Takemoto Hiromitsu Nagumo Eiichi Tanaka Naoshi Dohmae Takanori Nakane Ye Yu Ryuichiro Ishitani Osamu Matsuzaki Motoyuki Hattori Osamu Nureki
author_sort	Go Kasuya
title	Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
title_short	Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
title_full	Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
title_fullStr	Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
title_full_unstemmed	Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
title_sort	structural insights into the competitive inhibition of the atp-gated p2x receptor channel
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb0f6ce882154f37b17a413f1ef7ef0d
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Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

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