Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Abstract Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release o...

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Main Authors: Mégane Nascimento, Aurélie Gombault, Norinne Lacerda-Queiroz, Corinne Panek, Florence Savigny, Malak Sbeity, Manon Bourinet, Marc Le Bert, Nicolas Riteau, Bernhard Ryffel, Valérie F. J. Quesniaux, Isabelle Couillin
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/cb153acec13d4224a9663929f0a27175
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https://doaj.org/article/cb153acec13d4224a9663929f0a27175

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