Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Abstract Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release o...

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Autores principales:	Mégane Nascimento, Aurélie Gombault, Norinne Lacerda-Queiroz, Corinne Panek, Florence Savigny, Malak Sbeity, Manon Bourinet, Marc Le Bert, Nicolas Riteau, Bernhard Ryffel, Valérie F. J. Quesniaux, Isabelle Couillin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb153acec13d4224a9663929f0a27175
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spelling	oai:doaj.org-article:cb153acec13d4224a9663929f0a271752021-12-02T16:08:28ZSelf-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice10.1038/s41598-019-51427-y2045-2322https://doaj.org/article/cb153acec13d4224a9663929f0a271752019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51427-yhttps://doaj.org/toc/2045-2322Abstract Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interferon genes (STING), driving type I interferon (IFN I) dependent lung inflammation, which are attenuated in cGAS, STING or type I interferon receptor (IFNAR) deficient mice. Therefore, we demonstrate a critical role of self-dsDNA release and of the cGAS-STING-type I interferon pathway upon cigarette smoke-induced damage, which may lead to therapeutic targets in COPD.Mégane NascimentoAurélie GombaultNorinne Lacerda-QueirozCorinne PanekFlorence SavignyMalak SbeityManon BourinetMarc Le BertNicolas RiteauBernhard RyffelValérie F. J. QuesniauxIsabelle CouillinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mégane Nascimento Aurélie Gombault Norinne Lacerda-Queiroz Corinne Panek Florence Savigny Malak Sbeity Manon Bourinet Marc Le Bert Nicolas Riteau Bernhard Ryffel Valérie F. J. Quesniaux Isabelle Couillin Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice
description	Abstract Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interferon genes (STING), driving type I interferon (IFN I) dependent lung inflammation, which are attenuated in cGAS, STING or type I interferon receptor (IFNAR) deficient mice. Therefore, we demonstrate a critical role of self-dsDNA release and of the cGAS-STING-type I interferon pathway upon cigarette smoke-induced damage, which may lead to therapeutic targets in COPD.
format	article
author	Mégane Nascimento Aurélie Gombault Norinne Lacerda-Queiroz Corinne Panek Florence Savigny Malak Sbeity Manon Bourinet Marc Le Bert Nicolas Riteau Bernhard Ryffel Valérie F. J. Quesniaux Isabelle Couillin
author_facet	Mégane Nascimento Aurélie Gombault Norinne Lacerda-Queiroz Corinne Panek Florence Savigny Malak Sbeity Manon Bourinet Marc Le Bert Nicolas Riteau Bernhard Ryffel Valérie F. J. Quesniaux Isabelle Couillin
author_sort	Mégane Nascimento
title	Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice
title_short	Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice
title_full	Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice
title_fullStr	Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice
title_full_unstemmed	Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice
title_sort	self-dna release and sting-dependent sensing drives inflammation to cigarette smoke in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cb153acec13d4224a9663929f0a27175
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Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

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