Dysferlin-peptides reallocate mutated dysferlin thereby restoring function.

Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dystrophy, LGMD2B. There is no therapy. Dysferlin is a membrane protein comprised of seven, beta-sheet enriched, C2 domains and is involved in Ca(2+)dependent sarcolemmal repair after minute wounding. On the pro...

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Autores principales: Verena Schoewel, Andreas Marg, Severine Kunz, Tim Overkamp, Romy Siegert Carrazedo, Ute Zacharias, Peter T Daniel, Simone Spuler
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/cb39ce123be842d29078789a4fcd6651
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