Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype
The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy.
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Nature Portfolio
2018
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oai:doaj.org-article:cb4f389472124edeb3126b20dcd9ed152021-12-02T17:33:04ZClinical and genomic landscape of gastric cancer with a mesenchymal phenotype10.1038/s41467-018-04179-82041-1723https://doaj.org/article/cb4f389472124edeb3126b20dcd9ed152018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04179-8https://doaj.org/toc/2041-1723The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy.Sang Cheul OhBo Hwa SohnJae-Ho CheongSang-Bae KimJae Eun LeeKi Cheong ParkSang Ho LeeJong-Lyul ParkYun-Yong ParkHyun-Sung LeeHee-Jin JangEun Sung ParkSang-Cheol KimJeonghoon HeoIn-Sun ChuYou-Jin JangYoung-Jae MokWonKyung JungBaek-Hui KimAeree KimJae Yong ChoJae Yun LimYuki HayashiShumei SongElena ElimovaJeannelyn S. EstrallaJeffrey H. LeeManoop S. BhutaniYiling LuWenbin LiuJeeyun LeeWon Ki KangSung KimSung Hoon NohGordon B. MillsSeon-Young KimJaffer A. AjaniJu-Seog LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Sang Cheul Oh Bo Hwa Sohn Jae-Ho Cheong Sang-Bae Kim Jae Eun Lee Ki Cheong Park Sang Ho Lee Jong-Lyul Park Yun-Yong Park Hyun-Sung Lee Hee-Jin Jang Eun Sung Park Sang-Cheol Kim Jeonghoon Heo In-Sun Chu You-Jin Jang Young-Jae Mok WonKyung Jung Baek-Hui Kim Aeree Kim Jae Yong Cho Jae Yun Lim Yuki Hayashi Shumei Song Elena Elimova Jeannelyn S. Estralla Jeffrey H. Lee Manoop S. Bhutani Yiling Lu Wenbin Liu Jeeyun Lee Won Ki Kang Sung Kim Sung Hoon Noh Gordon B. Mills Seon-Young Kim Jaffer A. Ajani Ju-Seog Lee Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| description |
The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy. |
| format |
article |
| author |
Sang Cheul Oh Bo Hwa Sohn Jae-Ho Cheong Sang-Bae Kim Jae Eun Lee Ki Cheong Park Sang Ho Lee Jong-Lyul Park Yun-Yong Park Hyun-Sung Lee Hee-Jin Jang Eun Sung Park Sang-Cheol Kim Jeonghoon Heo In-Sun Chu You-Jin Jang Young-Jae Mok WonKyung Jung Baek-Hui Kim Aeree Kim Jae Yong Cho Jae Yun Lim Yuki Hayashi Shumei Song Elena Elimova Jeannelyn S. Estralla Jeffrey H. Lee Manoop S. Bhutani Yiling Lu Wenbin Liu Jeeyun Lee Won Ki Kang Sung Kim Sung Hoon Noh Gordon B. Mills Seon-Young Kim Jaffer A. Ajani Ju-Seog Lee |
| author_facet |
Sang Cheul Oh Bo Hwa Sohn Jae-Ho Cheong Sang-Bae Kim Jae Eun Lee Ki Cheong Park Sang Ho Lee Jong-Lyul Park Yun-Yong Park Hyun-Sung Lee Hee-Jin Jang Eun Sung Park Sang-Cheol Kim Jeonghoon Heo In-Sun Chu You-Jin Jang Young-Jae Mok WonKyung Jung Baek-Hui Kim Aeree Kim Jae Yong Cho Jae Yun Lim Yuki Hayashi Shumei Song Elena Elimova Jeannelyn S. Estralla Jeffrey H. Lee Manoop S. Bhutani Yiling Lu Wenbin Liu Jeeyun Lee Won Ki Kang Sung Kim Sung Hoon Noh Gordon B. Mills Seon-Young Kim Jaffer A. Ajani Ju-Seog Lee |
| author_sort |
Sang Cheul Oh |
| title |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_short |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_full |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_fullStr |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_full_unstemmed |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_sort |
clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/cb4f389472124edeb3126b20dcd9ed15 |
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1718380088589811712 |