Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and confer protection to systemic and local infec...

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Autores principales:	Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S. Meehan, Adam G. Nelson, David P. Fairlie, Jeffrey Y. W. Mak, Sidonia B. G. Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G. Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett, Zhenjun Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb7dc772b44d4a1993581d2bb0169b5d
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spelling	oai:doaj.org-article:cb7dc772b44d4a1993581d2bb0169b5d2021-12-02T15:33:16ZFrancisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection10.1038/s41467-021-24570-22041-1723https://doaj.org/article/cb7dc772b44d4a1993581d2bb0169b5d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24570-2https://doaj.org/toc/2041-1723Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and confer protection to systemic and local infection.Zhe ZhaoHuimeng WangMai ShiTianyuan ZhuTroi PediongcoXin Yi LimBronwyn S. MeehanAdam G. NelsonDavid P. FairlieJeffrey Y. W. MakSidonia B. G. EckleMarcela de Lima MoreiraCarolin TumpachMichael BramhallCameron G. WilliamsHyun Jae LeeAshraful HaqueMaximilien EvrardJamie RossjohnJames McCluskeyAlexandra J. CorbettZhenjun ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhe Zhao Huimeng Wang Mai Shi Tianyuan Zhu Troi Pediongco Xin Yi Lim Bronwyn S. Meehan Adam G. Nelson David P. Fairlie Jeffrey Y. W. Mak Sidonia B. G. Eckle Marcela de Lima Moreira Carolin Tumpach Michael Bramhall Cameron G. Williams Hyun Jae Lee Ashraful Haque Maximilien Evrard Jamie Rossjohn James McCluskey Alexandra J. Corbett Zhenjun Chen Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
description	Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and confer protection to systemic and local infection.
format	article
author	Zhe Zhao Huimeng Wang Mai Shi Tianyuan Zhu Troi Pediongco Xin Yi Lim Bronwyn S. Meehan Adam G. Nelson David P. Fairlie Jeffrey Y. W. Mak Sidonia B. G. Eckle Marcela de Lima Moreira Carolin Tumpach Michael Bramhall Cameron G. Williams Hyun Jae Lee Ashraful Haque Maximilien Evrard Jamie Rossjohn James McCluskey Alexandra J. Corbett Zhenjun Chen
author_facet	Zhe Zhao Huimeng Wang Mai Shi Tianyuan Zhu Troi Pediongco Xin Yi Lim Bronwyn S. Meehan Adam G. Nelson David P. Fairlie Jeffrey Y. W. Mak Sidonia B. G. Eckle Marcela de Lima Moreira Carolin Tumpach Michael Bramhall Cameron G. Williams Hyun Jae Lee Ashraful Haque Maximilien Evrard Jamie Rossjohn James McCluskey Alexandra J. Corbett Zhenjun Chen
author_sort	Zhe Zhao
title	Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
title_short	Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
title_full	Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
title_fullStr	Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
title_full_unstemmed	Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
title_sort	francisella tularensis induces th1 like mait cells conferring protection against systemic and local infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cb7dc772b44d4a1993581d2bb0169b5d
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Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

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