Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

Blockade of PD-L1 is usually not very effective in colon cancer patients. Here, the authors show the efficacy of PD-L1 blockade in combination with coordination polymer nanoparticles carrying oxaliplatin and a photosensitizer to induce anti-tumor immunity in metastatic models of colon cancer.

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Autores principales:	Chunbai He, Xiaopin Duan, Nining Guo, Christina Chan, Christopher Poon, Ralph R. Weichselbaum, Wenbin Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cba12bafd7ff4dc78c67844f9ae432d6
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spelling	oai:doaj.org-article:cba12bafd7ff4dc78c67844f9ae432d62021-12-02T16:57:39ZCore-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy10.1038/ncomms124992041-1723https://doaj.org/article/cba12bafd7ff4dc78c67844f9ae432d62016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12499https://doaj.org/toc/2041-1723Blockade of PD-L1 is usually not very effective in colon cancer patients. Here, the authors show the efficacy of PD-L1 blockade in combination with coordination polymer nanoparticles carrying oxaliplatin and a photosensitizer to induce anti-tumor immunity in metastatic models of colon cancer.Chunbai HeXiaopin DuanNining GuoChristina ChanChristopher PoonRalph R. WeichselbaumWenbin LinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunbai He Xiaopin Duan Nining Guo Christina Chan Christopher Poon Ralph R. Weichselbaum Wenbin Lin Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
description	Blockade of PD-L1 is usually not very effective in colon cancer patients. Here, the authors show the efficacy of PD-L1 blockade in combination with coordination polymer nanoparticles carrying oxaliplatin and a photosensitizer to induce anti-tumor immunity in metastatic models of colon cancer.
format	article
author	Chunbai He Xiaopin Duan Nining Guo Christina Chan Christopher Poon Ralph R. Weichselbaum Wenbin Lin
author_facet	Chunbai He Xiaopin Duan Nining Guo Christina Chan Christopher Poon Ralph R. Weichselbaum Wenbin Lin
author_sort	Chunbai He
title	Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
title_short	Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
title_full	Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
title_fullStr	Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
title_full_unstemmed	Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
title_sort	core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cba12bafd7ff4dc78c67844f9ae432d6
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Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

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