Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

RNA G-quadruplexes (RG4) occur in vivo and have regulatory roles in mRNA metabolism. Here the authors show that the guanine residue stretches at the 5’ end of tRNA-derived stress-induced RNAs mediate the formation of tetramolecular RG4 structures, which play a role in the post-transcriptional regula...

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Autores principales:	Shawn M. Lyons, Dorota Gudanis, Steven M. Coyne, Zofia Gdaniec, Pavel Ivanov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cba8c36886fd443aa55acf7c6f648780
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spelling	oai:doaj.org-article:cba8c36886fd443aa55acf7c6f6487802021-12-02T15:38:43ZIdentification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs10.1038/s41467-017-01278-w2041-1723https://doaj.org/article/cba8c36886fd443aa55acf7c6f6487802017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01278-whttps://doaj.org/toc/2041-1723RNA G-quadruplexes (RG4) occur in vivo and have regulatory roles in mRNA metabolism. Here the authors show that the guanine residue stretches at the 5’ end of tRNA-derived stress-induced RNAs mediate the formation of tetramolecular RG4 structures, which play a role in the post-transcriptional regulation of gene expression.Shawn M. LyonsDorota GudanisSteven M. CoyneZofia GdaniecPavel IvanovNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shawn M. Lyons Dorota Gudanis Steven M. Coyne Zofia Gdaniec Pavel Ivanov Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
description	RNA G-quadruplexes (RG4) occur in vivo and have regulatory roles in mRNA metabolism. Here the authors show that the guanine residue stretches at the 5’ end of tRNA-derived stress-induced RNAs mediate the formation of tetramolecular RG4 structures, which play a role in the post-transcriptional regulation of gene expression.
format	article
author	Shawn M. Lyons Dorota Gudanis Steven M. Coyne Zofia Gdaniec Pavel Ivanov
author_facet	Shawn M. Lyons Dorota Gudanis Steven M. Coyne Zofia Gdaniec Pavel Ivanov
author_sort	Shawn M. Lyons
title	Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
title_short	Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
title_full	Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
title_fullStr	Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
title_full_unstemmed	Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
title_sort	identification of functional tetramolecular rna g-quadruplexes derived from transfer rnas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cba8c36886fd443aa55acf7c6f648780
work_keys_str_mv	AT shawnmlyons identificationoffunctionaltetramolecularrnagquadruplexesderivedfromtransferrnas AT dorotagudanis identificationoffunctionaltetramolecularrnagquadruplexesderivedfromtransferrnas AT stevenmcoyne identificationoffunctionaltetramolecularrnagquadruplexesderivedfromtransferrnas AT zofiagdaniec identificationoffunctionaltetramolecularrnagquadruplexesderivedfromtransferrnas AT pavelivanov identificationoffunctionaltetramolecularrnagquadruplexesderivedfromtransferrnas
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Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

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