Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families

Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families

Abstract It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial BC cases. No candid...

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Auteurs principaux: Thibaut S. Matis, Nadia Zayed, Bouchra Labraki, Manon de Ladurantaye, Théophane A. Matis, José Camacho Valenzuela, Nancy Hamel, Adrienne Atayan, Barbara Rivera, Yuval Tabach, Patricia N. Tonin, Alexandre Orthwein, Anne-Marie Mes-Masson, Zaki El Haffaf, William D. Foulkes, Paz Polak
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Accès en ligne:https://doaj.org/article/cbb6acef8a0543f6b4e46805a7d21ec0
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https://doaj.org/article/cbb6acef8a0543f6b4e46805a7d21ec0

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