Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W

UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb and apply the mAbs to map endogenous UBE2W substr...

Full description

Saved in:
Bibliographic Details
Main Authors: Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/cbfb2674260f4b51a1c495c83e07dcb5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/cbfb2674260f4b51a1c495c83e07dcb5

Similar Items