ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells

Abstract Genes encoding replication-dependent histones lack introns, and the mRNAs produced are a unique class of RNA polymerase II transcripts in eukaryotic cells that do not end in a polyadenylated tail. Mature mRNAs are thus formed by a single endonucleolytic cleavage that releases the pre-mRNA f...

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Bibliographic Details
Main Authors: Ankur Gadgil, Agnieszka Walczak, Agata Stępień, Jonas Mechtersheimer, Agnes Lumi Nishimura, Christopher E. Shaw, Marc-David Ruepp, Katarzyna Dorota Raczyńska
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/cc016ad4171f42469bc5c1df58514821
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