A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors

Nanoparticle-based chemophotothermal therapy (CPT) is a promising treatment for multidrug resistant tumors. In this study, a drug nanococktail of DIR825@histone was developed by employing doxorubicin (DOX), NIR dye IR825 and human histones for interventional nucleus-targeted CPT of multidrug resista...

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Autores principales:	Jianquan Guo, Dongsheng Tan, Chenmei Lou, Shiying Guo, Xing Jin, Haijing Qu, Lijia Jing, Sijin Li
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Human histones Chemotherapy Photothermal therapy Nuclear targeting Localized intervention Drug resistant tumor Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cc4b0abac14d4b2c8edd406d42ac2b03
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spelling	oai:doaj.org-article:cc4b0abac14d4b2c8edd406d42ac2b032021-11-10T04:30:36ZA tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors2452-199X10.1016/j.bioactmat.2021.07.018https://doaj.org/article/cc4b0abac14d4b2c8edd406d42ac2b032022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003492https://doaj.org/toc/2452-199XNanoparticle-based chemophotothermal therapy (CPT) is a promising treatment for multidrug resistant tumors. In this study, a drug nanococktail of DIR825@histone was developed by employing doxorubicin (DOX), NIR dye IR825 and human histones for interventional nucleus-targeted CPT of multidrug resistant tumors with an interventional laser. After localized intervention, DIR825@histone penetrated tumor tissues by transcytosis, efficiently entered tumor cells and targeted the cell nuclei. DIR825@histone also exhibited good photothermal performance and thermal-triggered drug release. Efficient multidrug resistant tumor inhibition was achieved by enhanced CPT sensitization and MDR reversion via nuclear targeting. Moreover, an interventional laser assisted DIR825@histone in inhibiting multidrug resistant tumors by promoting the sufficient delivery of laser energy inside the tumor while reducing skin injury. Therefore, DIR825@histone together with this interventional nucleus-targeted CPT strategy holds great promise for treating multidrug resistant tumors.Jianquan GuoDongsheng TanChenmei LouShiying GuoXing JinHaijing QuLijia JingSijin LiKeAi Communications Co., Ltd.articleHuman histonesChemotherapyPhotothermal therapyNuclear targetingLocalized interventionDrug resistant tumorMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 9, Iss , Pp 554-565 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Human histones Chemotherapy Photothermal therapy Nuclear targeting Localized intervention Drug resistant tumor Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Human histones Chemotherapy Photothermal therapy Nuclear targeting Localized intervention Drug resistant tumor Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Jianquan Guo Dongsheng Tan Chenmei Lou Shiying Guo Xing Jin Haijing Qu Lijia Jing Sijin Li A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
description	Nanoparticle-based chemophotothermal therapy (CPT) is a promising treatment for multidrug resistant tumors. In this study, a drug nanococktail of DIR825@histone was developed by employing doxorubicin (DOX), NIR dye IR825 and human histones for interventional nucleus-targeted CPT of multidrug resistant tumors with an interventional laser. After localized intervention, DIR825@histone penetrated tumor tissues by transcytosis, efficiently entered tumor cells and targeted the cell nuclei. DIR825@histone also exhibited good photothermal performance and thermal-triggered drug release. Efficient multidrug resistant tumor inhibition was achieved by enhanced CPT sensitization and MDR reversion via nuclear targeting. Moreover, an interventional laser assisted DIR825@histone in inhibiting multidrug resistant tumors by promoting the sufficient delivery of laser energy inside the tumor while reducing skin injury. Therefore, DIR825@histone together with this interventional nucleus-targeted CPT strategy holds great promise for treating multidrug resistant tumors.
format	article
author	Jianquan Guo Dongsheng Tan Chenmei Lou Shiying Guo Xing Jin Haijing Qu Lijia Jing Sijin Li
author_facet	Jianquan Guo Dongsheng Tan Chenmei Lou Shiying Guo Xing Jin Haijing Qu Lijia Jing Sijin Li
author_sort	Jianquan Guo
title	A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
title_short	A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
title_full	A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
title_fullStr	A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
title_full_unstemmed	A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
title_sort	tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/cc4b0abac14d4b2c8edd406d42ac2b03
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A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors

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